Recent Publications (with Abstracts)

Duell, E.J.; Travier, N.; Lujan-Barroso, L.; Boutron-Ruault, M.C.; Clavel-Chapelon, F.; Palli, D.; Krogh, V.; Mattiello, A.; Tumino, R.; Sacerdote, C.; Rodriguez, L.; Sanchez-Cantalejo, E.; Navarro, C.; Barricarte, A.; Dorronsoro, M.; Khaw, K.T.; Wareham, N.; Allen, N.E.; Tsilidis, K.K.; Bueno-de-Mesquita, H.B.; Jeurnink, S.M.; Numans, M.E.; Peeters, P.H.; Lagiou, P.; Valanou, E.; Trichopoulou, A.; Kaaks, R.; Lukanova-McGregor, A.; Bergman, M.M.; Boeing, H.; Manjer, J.; Lindkvist, B.; Stenling, R.; Hallmans, G.; Dahm, C.C.; Overvad, K.; Olsen, A.; Tjonneland, A.; Bakken, K.; Lund, E.; Jenab, M.; McCormack, V.; Rinaldi, S.; Michaud, D.; Mouw, T.; Nesi, G.; Carneiro, F.; Riboli, E.; Gonzalez, C.A. (2010) Menstrual and Reproductive Factors, Exogenous Hormone Use, and Gastric Cancer Risk in a Cohort of Women From the European Prospective Investigation Into Cancer and Nutrition Am J Epidemiol, , [] Online
Abstract: The worldwide incidence of gastric adenocarcinoma (GC) is lower in women than in men. Furthermore, cancer patients treated with estrogens have been reported to have a lower subsequent risk of GC. The authors conducted a prospective analysis of menstrual and reproductive factors, exogenous hormone use, and GC in 335,216 women from the European Prospective Investigation Into Cancer and Nutrition, a cohort study of individuals aged 35-70 years from 10 European countries. After a mean follow-up of 8.7 years (through 2004), 181 women for whom complete exposure data were available developed GC. Adjusted hazard ratios and 95% confidence intervals were estimated using Cox proportional hazards models. All statistical tests were 2-sided. Women who had ovariectomy had a 79% increased risk of GC (based on 25 cases) compared with women who did not (hazard ratio = 1.79, 95% confidence interval: 1.15, 2.78). Total cumulative years of menstrual cycling was inversely associated with GC risk (fifth vs. first quintile: hazard ratio = 0.55, 95% confidence interval: 0.31, 0.98; P(trend) = 0.06). No other reproductive factors analyzed were associated with risk of GC. The results of this analysis provide some support for the hypothesis that endogenous ovarian sex hormones lower GC incidence in women.
PubMed Accession Number :: 21051447.

Ridgway, C.L.; Brage, S.; Anderssen, S.; Sardinha, L.B.; Andersen, L.B.; Ekelund, U. (2010) Fat-free mass mediates the association between birth weight and aerobic fitness in youth Int J Pediatr Obes, , [Journal Article] Online
Abstract: Abstract Objective. To investigate whether birth weight acts as a biological determinant of later aerobic fitness, and whether fat-free mass may mediate this association. Methods. The European Youth Heart Study (EYHS) is a population-based cohort of two age groups (9 and 15 years) from Denmark, Portugal, Estonia and Norway. Children with parentally reported birth weight >1.5 kg were included (n = 2 749). Data were collected on weight, height, and skinfold measures to estimate fat mass and fat-free mass. Aerobic fitness (peak power, watts) was assessed using a maximal, progressive cycle ergometer test. Physical activity was collected in a subset (n = 1 505) using a hip-worn accelerometer and defined as total activity counts/wear time, all children with >600 minutes/day for >/=3 days of wear were included. Results. Lower birth weight was associated with lower aerobic fitness, after adjusting for sex, age group, country, sexual maturity and socio-economic status (ss = 5.4; 95% CI: 3.5, 7.3 W per 1 kg increase in birth weight, p < 0.001). When fat-free mass was introduced as a covariate in the model, the association between birth weight and aerobic fitness was almost completely attenuated (p = 0.7). Birth weight was also significantly associated with fat-free mass (ss = 1.4; 95% CI: 1.1, 1.8, p < 0.001) and fat-free mass was significantly associated with aerobic fitness (ss = 3.6; 95% CI: 3.4, 3.7, p < 0.001). Further adjustment for physical activity did not alter the findings. Conclusion. Birth weight may have long-term influences on fat-free mass and differences in fat-free mass mediate the observed association between birth weight and aerobic fitness.
PubMed Accession Number :: 21050079.

Tillin, T.; Forouhi, N.G.; McKeigue, P.M.; Chaturvedi, N. (2010) Southall And Brent REvisited: Cohort profile of SABRE, a UK population-based comparison of cardiovascular disease and diabetes in people of European, Indian Asian and African Caribbean origins Int J Epidemiol, , [Journal Article] Online
PubMed Accession Number :: 21044979.

Leufkens, A.M.; van Duijnhoven, F.J.; Siersema, P.D.; Boshuizen, H.C.; Vrieling, A.; Agudo, A.; Gram, I.T.; Weiderpass, E.; Dahm, C.; Overvad, K.; Tjonneland, A.; Olsen, A.; Boutron-Ruault, M.C.; Clavel-Chapelon, F.; Morois, S.; Palli, D.; Grioni, S.; Tumino, R.; Sacerdote, C.; Mattiello, A.; Herman, S.; Kaaks, R.; Steffen, A.; Boeing, H.; Trichopoulou, A.; Lagiou, P.; Trichopoulos, D.; Peeters, P.H.; van Gils, C.H.; van Kranen, H.; Lund, E.; Dumeaux, V.; Engeset, D.; Rodriguez, L.; Sanchez, M.J.; Chirlaque, M.D.; Barricarte, A.; Manjer, J.; Almquist, M.; van Guelpen, B.; Hallmans, G.; Khaw, K.T.; Wareham, N.; Tsilidis, K.K.; Straif, K.; Leon-Roux, M.; Vineis, P.; Norat, T.; Riboli, E.; Bueno-de-Mesquita, H.B. (2010) Cigarette Smoking and colorectal cancer risk in the EPIC study Clin Gastroenterol Hepatol, , [Journal Article] Online
Abstract: BACKGROUND & AIMS:: There has been consistent evidence for a relationship between smoking and colorectal cancer (CRC), although it is not clear whether the colon or rectum is more sensitive to the effects of smoking. We investigated the relationships between cigarette smoking and risk of CRC and tumor location. METHODS:: We analyzed data from 465,879 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) study; 2,741 developed CRC during the follow-up period (mean 8.7 years). Cox proportional hazard regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (95% CIs). RESULTS:: The risk of colon carcinoma was increased among ever smokers (HR 1.18, 95%CI 1.06-1.32) and former cigarette smokers (HR 1.21, 95%CI 1.08-1.36), compared with never smokers; the increased risk for current smokers was of borderline significance (HR 1.13, 95%CI 0.98-1.31). When stratified for tumor location, the risk of proximal colon cancer was increased for former (HR 1.25, 95%CI 1.04-1.50) and current smokers (HR 1.31, 95%CI 1.06-1.64), but the risks for cancers in the distal colon or rectum were not. Subsite analyses showed a non-significant difference between the proximal and distal colon (p=0.45) for former smokers and a significant difference for current smokers (p=0.02). For smokers that had stopped smoking for at least 20 years, the risk of developing colon cancer was similar to that of never smokers. CONCLUSIONS:: Ever smokers have an increased risk of colon cancer, which appeared to be more pronounced in the proximal than the distal colon location.
PubMed Accession Number :: 21029790.

Buchner, F.L.; Bueno-de-Mesquita, H.B.; Ros, M.M.; Kampman, E.; Egevad, L.; Overvad, K.; Tjonneland, A.; Roswall, N.; Clavel-Chapelon, F.; Boutron-Ruault, M.C.; Touillaud, M.; Kaaks, R.; Chang-Claude, J.; Boeing, H.; Weikert, S.; Trichopoulou, A.; Naska, A.; Benetou, V.; Palli, D.; Sieri, S.; Vineis, P.; Tumino, R.; Panico, S.; van Duijnhoven, F.J.; Peeters, P.H.; van Gils, C.H.; Lund, E.; Gram, I.T.; Sanchez, M.J.; Jakszyn, P.; Larranaga, N.; Ardanaz, E.; Navarro, C.; Rodriguez, L.; Manjer, J.; Ehrnstrom, R.; Hallmans, G.; Ljungberg, B.; Key, T.J.; Allen, N.E.; Khaw, K.T.; Wareham, N.; Slimani, N.; Jenab, M.; Boffetta, P.; Kiemeney, L.A.; Riboli, E. (2010) Variety in vegetable and fruit consumption and risk of bladder cancer in the European Prospective Investigation into Cancer and Nutrition Int J Cancer, , [Journal Article] Online
Abstract: Recent research does not show an association between fruit and vegetable consumption and bladder cancer risk. None of these studies investigated variety in fruit and vegetable consumption, which may capture different aspects of consumption. We investigated whether a varied consumption of vegetables and fruits is associated with bladder cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Detailed data on food consumption and complete follow-up for cancer incidence were available for 452,185 participants, who were recruited from ten European countries. After a mean follow-up of 8.7 years, 874 participants were diagnosed with bladder cancer. Diet diversity scores (DDSs) were used to quantify the variety in fruit and vegetable consumption. Multivariable Cox proportional hazard models were used to assess the effect of the DDSs on bladder cancer risk. There was no evidence of a statistically significant association between bladder cancer risk and any of the DDSs when these scores were considered as continuous covariates. However, the hazard ratio (HR) for the highest tertile of the DDS for combined fruit and vegetable consumption was marginally significant compared to the lowest (HR = 1.30, 95% confidence interval: 1.00-1.69, p-trend = 0.05). In EPIC, there is no clear association between a varied fruit and vegetable consumption and bladder cancer risk. This finding provides further evidence for the absence of any strong association between fruit and vegetable consumption as measured by a food frequency questionnaire and bladder cancer risk.
PubMed Accession Number :: 20979109.