Information about genetic and phenotypic risk of T2DM is now widely available but whether such information generates anxiety and/or motivates behaviour change is unknown. In the Diabetes Risk Communication trial 569 middle-aged, non-diabetic adults who consented to taking part received either standard lifestyle advice alone (control group), or in combination with either genetic or a phenotypic risk estimate for T2DM. The primary outcome of objectively measured physical activity (combined sensing) and secondary outcomes (self-reported diet weight, worry, anxiety, and perceived risk) were measured at 8 weeks post-intervention. A post-intervention questionnaire assessed acceptance and putative mediating variables.
MRC core funding.