Current operational status
In response to the coronavirus (COVID-19) outbreak Unit members are working from home until further notice, and all internal and external meetings are being held via video or teleconferencing.
Field testing and volunteers
All active field testing as part of our research studies that involves direct contact with volunteers has been temporarily suspended, and all volunteers who had appointments booked have been notified that they have been postponed or cancelled. For any enquiries about a study you are participating in please check the contact details for individual studies on our Study Contacts web page, or email us at: firstname.lastname@example.org
Thank you for your patience at this difficult time.
The MRC Epidemiology Unit/CEDAR external seminar series has been moved online, where they are provided for free and with no need to register. You can find a list of upcoming seminars on our Events page, and you can subscribe on our online form to receive emails about future seminars and other alerts.
University of Cambridge response
University of Cambridge Coronavirus support pages can be found at www.cam.ac.uk/coronavirus
Our research response
The research work of the Unit is continuing, and Unit scientists are also exploring opportunities to contribute to national efforts, both in response to the COVID-19 pandemic and its broader public health consequences.
Several of our staff are now helping directly with the COVID-19 crisis, working in clinical, public health or lab testing settings, while members of our Global Public Health Research team are leading efforts to crowd-source the translation of WHO facts on Coronavirus into as many African languages as possible.
A major research undertaking is to plan the roll out of a digital platform for obtaining serial information on symptoms and signs of COVID-19 over the next year in the Fenland study with measurement of antibody status when this is available. The aim is to identify early markers of the transition from asymptomatic to symptomatic COVID-19 infection. Update on this here!
Our public health programmes are engaged nationally and internationally in determining the implications for diet and activity behaviours of the epidemic in terms of food security and the impact on physical activity of the social distancing restrictions.
Finally, members of our genetics programme have joined the COVID-19 host genetics initiative which aims to bring together the human genetics community to generate, share, and analyse data to learn about the genetic determinants of COVID-19 susceptibility, severity and outcomes.
Updates on ongoing Unit research related to COVID-19 and its public health consequences are below.
Consortium led by Unit researchers develops open platform to help discover COVID-19 drugs – December 2020
An international consortium led by MRC researchers has developed an open access platform to help prioritise drug discovery and repurposing efforts for the current COVID-19 pandemic. The platform provides information on the genetic variation of host proteins involved in SARS-CoV-2 infection, based on analysis of genetic and proteomic data from 10,708 Fenland Study participants.
- Read the full story
- Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison ND et al. Genetic architecture of host proteins involved in SARS-CoV-2 infection. Nature Communications, 16 December 2020. DOI: 10.1038/s41467-020-19996-z
- Omicscience open access platform: https://omicscience.org/apps/covidpgwas/
Quarterly report on progress to address COVID-19 health inequalities – Race Disparities Unit – October 2020
Dr Raghib Ali was announced as a one of the Government’s new expert advisers on COVID and ethnicity on 22 October, and with Professor Keith Neal of the University of Nottingham briefed science journalists at a Science Media Centre on the Government’s Race Disparities Unit’s first quarterly report on progress to address COVID health inequalities, with particular reference to ethnicity. Dr Ali explained how understanding of risk factors has improved since the Public Health England report in June, and described the action government has taken to date and outline future steps to address disparities.
The report was presented to the Prime Minister by the Equalities Minister, Kemi Badenoch, who also update the House of Commons on progress described in the report on Thursday 22 October.
Research helps NHS support people with diabetes during coronavirus – September 2020
MRC Epidemiology Unit Director Nick Wareham has contributed to recent research that is being used to help the NHS offer greater support to those with diabetes. The research, published in in two papers in Lancet Diabetes and Endocrinology shows that people living with diabetes face a significantly higher risk of dying with COVID-19. A third of deaths in England are associated with the condition. As a result of this research, the NHS in England has called on people with diabetes to access help available to them, including a new dedicated helpline and online tools to help manage the condition during the outbreak.
Vitamin D for COVID-19: a case to answer? – September 2020
In a comment article in the Lancet Diabetes & Endocrinology, Unit scientist Professor Nita Forouhi and Professor Adrian Martineau of the Blizard Institute discuss the available evidence for a role for Vitamin D in preventing or treating COVID -19 infection.
They note that current evidence is inconclusive and recommend population-based trials investigating vitamin D supplementation as a means of reducing the severity of COVID-19. In meantime they urge measures to ensure that people achieve recommended daily amounts of Vitamin D (10 micrograms per day for adults in the UK) saying this “might also reduce the impact of COVID-19 in populations where vitamin D deficiency is prevalent; there is nothing to lose from their implementation, and potentially much to gain.”
- Read: Martineau AR, Forouhi NG. Vitamin D for COVID-19: a case to answer? Lancet Diabetes & Endocrinology (2020) 8:9, 735-736.
Unit launches study to monitor COVID-19 in 12,000 Cambridgeshire residents – July 2020
Participants in Cambridgeshire’s Fenland Study are being invited to join an innovative study that will use a home-administered blood sampling device – the Drawbridge Health OneDraw device – to find out how many have evidence in their blood of previous COVID-19 infection.
The primary aim of this study is to quantify the proportion of people who have had COVID-19 in the Fenland cohort, and participants will be tested several times over the duration of the study allow researchers to identify new as well as existing COVID-19 cases. Researchers will also be able to determine if those with COVID-19 antibodies at the start of the study continue to have positive antibody status over the study period, or if antibody levels decline over time.
The study will also investigate whether it is possible to identify the COVID-19 pre-symptomatic phase using measurement of signs and symptoms collected via a smartphone App developed by Huma. Participants will use a smartphone app to record measurements such as heart rate, heart rate variability, respiratory rate, blood oxygen, and temperature. Participants will also enter health information such as body weight and diet changes, medication and supplement use, their mental health and wellbeing, and COVID-19 symptoms and potential risk factors.
Earlier lockdown restrictions linked to greater reduction in new COVID-19 cases – July 2020
A BMJ paper by Dr Nazrul Islam and colleagues – including senior author Professor Martin White at the MRC Epidemiology Unit – examines the association between implementation of physical distancing interventions and new cases of COVID-19 in 149 countries and regions.
Their findings show that physical distancing measures, such as closing schools, workplaces, and public transport, restricting mass gatherings, and restrictions on people’s movement within countries or regions (‘lockdown’), were associated with an overall reduction of 13% in new COVID-19 cases in a study period of up to 30 days after implementation of the measures .
The data also shows that implementing physical distancing measures earlier was associated with a greater reduction in new cases, and that in combination with school and workplace closure, restriction on mass gatherings seemed to be a key component associated with a decrease in COVID-19 incidence.
- Read: Islam N, Sharp SJ, Chowell G, Shabnam S, Kawachi I, Lacey B, Massaro JM, D’Agostino Sr RB, White M. Physical distancing interventions and incidence of coronavirus disease 2019: natural experiment in 149 countries BMJ 2020;370:m2743
- Read the Nuffield Department of Public Health news report
Genetic architecture of host proteins interacting with SARS-CoV-2 – July 2020
A team led by Unit researcher Dr Claudia Langenberg has published in Omicscience summary statistics for large-scale genomic and plasma proteomic data from over 10,000 individuals to characterise genetic architecture of host proteins reported to interact with SARS-CoV-2. This accompanies the submission of the paper “Genetic architecture of host proteins interacting with SARS-CoV” which is available on BioRxiv.
The summary statistics freely available without restrictions, and include an interactive matrix and annotations for all protein targets and cis-associated genetic loci, as well as interactive tables with pGWAS summary statistics for individual SNPs, genes, or genetic regions from which results can be sorted, filtered, and exported.
- Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Johannes Raffler, Nicola D. Kerrison et al. Genetic architecture of host proteins interacting with SARS-CoV-2. BioRxiv. 01 July 2020.
- Summary statistics on Omicscience
Sentiment and opinion analysis of public space physical activity in Lagos during lockdown – June 2020
Research has started on a Cambridge Africa Alborada COVID emergency call award: Sentiment and opinion analysis of public space physical activity in Lagos during lockdown: a data-driven approach to developing context-aware public health messaging to reduce disease vulnerability and improve COVID-19 control.
This project is led by Tolu Oni from our Global Public Health Research programme, and is a collaboration with Associate Professor Taibat Lawanson at the University of Lagos Centre for housing and sustainable development and Associate Professor Camaren Peter at the Graduate School of Business and Centre for Analytics and Behavioural Change at the University of Cape Town.
This project aims to conduct opinion analyses of public space leisure physical activity to explore perceptions of government lockdown restrictions (and enforcement), and the impact of these lockdown measures on the perceptions, nature and frequency of appropriation of public space for activity in Lagos. Findings will inform development of context-aware public health messaging that safely encourages physical activity in the short term and health foresight interventions to reduce co-morbidity-associated vulnerability to future health emergencies long-term.
- Sentiment and opinion analysis of public space physical activity in Lagos during lockdown – Cambridge Africa updates
COVID-19 and ethnicity: who will research results apply to? – June 2020
In June Professor Nita Forouhi was an author on the Lancet Comment article “COVID-19 and ethnicity: who will research results apply to?”.
- Read: Treweek S, Forouhi NG, Venkat Narayan KM, Khunti K. COVID-19 and ethnicity: who will research results apply to? Lancet (2020) 395(10242): 1955-1957
Recruitment starts for SWiM-C: Supporting Weight Management during COVID-19 – June 2020
Recruitment has started for the Supporting Weight Management during COVID-19 (SWiM-C) study, which seeks to evaluate whether a new online self-help programme is better than standard advice at helping people to prevent weight gain and supporting good physical and mental health.
SWIM-C is recruiting 360 adults adults (aged over 18 years) with overweight or obesity and access to weighing scales at home
Update 9 September 2020: Recruitment to the SWiM-C study has now finished. Many thanks to everyone who contacted us to enquire about participating in this study, and enabled us to reach our recruitment target.
- More information about SWIM-C and how to participate
- Contact the SWIM-C study team at: email@example.com
OneDraw feasibility study launches – June 2020
Social distancing measures and new ways of working mean that new methods of blood sample collection are urgently needed for Unit studies. In preparation for a large-scale surveillance study in the Fenland cohort to determine the prevalence of previous infection with COVID-19, a study has been launched to evaluate a self-applied blood collection using a device called OneDraw.
It is important that we obtain adequate blood samples from participants using the dried blood spot (DBS) method that can be standardised as far as possible to undertake the COVID-19 serological testing repeatedly over a 6-month period.
- More information about the OneDraw feasibility study and how to participate
- Contact the OneDraw feasibility study team at firstname.lastname@example.org
NIHR video appeal for people from BAME backgrounds to take part in COVID-19 Research – May 2020
Professor Nita Forouhi of our Nutritional Epidemiology programme helped to organise, and featured in, a video appeal by the National Institute for Health Research (NIHR) for more people from Black, Asian and minority ethnic (BAME) backgrounds to take part in COVID-19 research studies.
Alongside Professor Forouhi the video featured British actors, comedians and broadcasters Omid Djalili and Sanjeev Bhasker, and American Oscar winning actor Whoopi Goldberg, as well as Professors Kamlesh Khunti and Azhar Farooqi from the University of Leicester. The appeal was shared widely on social media, with the Omid Djalili’s twitter video viewed more than 125,000 times, and was reported in more than two hundred local and regional UK print and online news outlets.
- Watch the NIHR video appeal on YouTube
- NIHR information on the COVID-19 research in Black, Asian and minority ethnic communities appeal
Analysis of NHS health records of 3.8 million adults yields estimate of COVID-19 mortality according to underlying conditions and age – May 2020
An analysis published by a team of scientists that includes Unit researcher Dr Claudia Langenberg and colleagues at UCL, University College London Hospitals NHS Foundation Trust, and Health Data Research UK, indicates that at least 20% of the UK population has a high-risk underlying condition for COVID-19 infection listed by Public Health England.
The authors have created a publicly accessible COVID -19 risk calculator showing how age, sex and underlying health conditions can affect mortality rates in different scenarios. They write that the analysis, which used NHS health records from 3.8 million adults in England, shows that the UK government must ensure that measures to ease the lockdown take into account this clinical vulnerability.
- Read Banerjee A, Pasea L, Harris S, Gonzalez-Izquierdo A, Torralbo A et al. Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study. Lancet May 12, 2020 DOI: 10.1016/S0140-6736(20)30854-0
- Read the UCL News report (12 May 2020)
- OurRisk.CoV calculator
A preprint of this paper was published as a ResearchGate Rapid Communication on 22 March 2020.
- Read Rapid communication published on 22 March 2020: Spiros Denaxas, Harry Hemingway, Laura Shallcross, Mahdad Noursadeghi, Bryan Williams et al. Estimating excess 1- year mortality from COVID-19 according to underlying conditions and age in England: a rapid analysis using NHS health records in 3.8 million adults. Rapid communication 22 March 2020. DOI:10.13140/RG.2.2.36151.27047
- Read the UCL News report (22 March 2020)
COVID-19 prevention information translated into several widely spoken African languages – April 2020
An Engage Africa Foundation translation team led by Dr Ebele Mogo, a member of the Global Diet and Activity Research (GDAR) Network, has translated information on preventing the transmission of COVID-19 into 19 languages spoken across Africa.
Select a language, click, and download at http://www.engageafricafoundation.org/covid-19
The Unit is a founding member of GDAR, which is funded through the NIHR Global Health Research initiative. GDAR`s goal is to help prevent non-communicable diseases, such as type 2 diabetes, heart disease, and cancers, in low and middle income countries.
- Found in Translation – University of Cambridge Stories article on the crowdsourced volunteer translation initiative led by Dr Ebele Mogo and the Engage Africa Foundation.
School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic review – April 2020
Researchers including Dr Oliver Mytton undertook a systematic review of published and pre-published studies to identify what is known about the effectiveness of school closures and other school social distancing practices during coronavirus outbreaks They conclude that school closures have much less impact on the spread of these viruses than other social distancing interventions, and recommend that policy makers need to be aware of the equivocal evidence when considering school closures for COVID-19, and consider combinations of social distancing measures.
- Read Russell M Viner, Simon J Russell, Helen Croker, Jessica Packer, Joseph Ward et al. School closure and management practices during coronavirus outbreaks including COVID-19: a rapid systematic review. Lancet Child Adolesc Health. 6 April 2020 S2352-4642(20)30095-X. DOI: 10.1016/S2352-4642(20)30095-X.
- Reported by the BBC, Guardian, Telegraph, and several other UK and international news outlets.
Slum Health: Arresting COVID-19 & Improving Well-Being in Urban Informal Settlements – 5 April 2020
Dr Tolullah Oni of our Global Public Health Research programme was part of an international team of reseachers that pre-published a set of practice and policy recommendations that aim to dampen the spread of COVID-19, improve the likelihood of medical care for the urban poor whether or not they get infected, and provide economic, social and physical improvements and protections to the urban poor that can improve their long-term well-being.
- Read Jason Corburn, David Vlahov, Blessing Mberu, Lee Riley, Waleska Teixeira Caiaffa et al. Slum Health: Arresting COVID-19 & Improving Well-Being in Urban Informal Settlements. Journal of Urban Health (2020) 97, 348–357.