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Seminar – Longitudinal growth modeling: a tool for genetic discovery

February 15 @ 1:30 pm - 2:30 pm

All are invited to the CEDAR/MRC Epidemiology Seminar by:

Dr Diana Cousminer, Children’s Hospital of Philadelphia, University of Philadelphia.

Longitudinal growth modeling: a tool for genetic discovery

Seminar room 2, University of Cambridge School of Clinical Medicine, CB2 0SP

Abstract

Distinct growth patterns during adolescence correlate with adverse health outcomes such as poor cardiometabolic health and risk for osteoporosis, but the genetic mechanisms mediating differences in growth trajectories remain largely unknown. Longitudinal modeling using SuperImposition by Translation and Rotation (SITAR) breaks down complex growth trajectories into three components, “size”, “timing”, and “velocity.” We utilize these parameters as phenotypes for input into genome-wide association studies (GWAS), to better understand the genetic determinants of increase in bone mineral density at distinct skeletal sites and height growth.

About Dr Cousminer 

Dr Diana Cousminer is a Postdoctoral Research Fellow at the Children’s Hospital of Philadelphia and the University of Pennsylvania. She received her PhD in Medical Genetics from the University of Helsinki and the Institute for Molecular Medicine Finland. Dr Cousminer’s work focuses on the genetics of early life traits, in particular the timing of puberty and pubertal growth, and how these traits are linked to later life health outcomes such as diabetes, cardiometabolic health, and osteoporosis.

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Details

Date:
February 15
Time:
1:30 pm - 2:30 pm

Venue

Seminar room 2, University of Cambridge School of Clinical Medicine, CB2 0SP
University of Cambridge School of Clinical Medicine
Cambridge, CB2 0SP United Kingdom
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