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Seminar – Diabetes No More: lessons from the DiRECT trial and beyond

February 20, 2023 @ 1:00 pm - 2:00 pm

All are invited to the MRC Epidemiology Seminar:

Diabetes No More: lessons from the DiRECT trial and beyond

Professor Mike Lean, University of Glasgow

This hybrid seminar was held in the meeting rooms, Level 4, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, and online.

Watch a recording of this seminar on YouTube.

About this talk

Three RCT trials, conducted entirely in primary care using low-calorie formula diets for 8-12 weeks, have reported remissions for 40-60% of participants including South Asians, and 70-80% with weight loss >10kg, well maintained at 2 years. Hypertension and NAFLD, commonly accompanying T2D, normalized for ~30%. Remission was accompanied by normalization of ectopic fat in liver and pancreas, and insulin production capacity. With fewer serious adverse events, total medical care costs fell and cost-effectiveness analysis projected people to live longer, feel better and cost less. Remissions are strongly driven by weight loss, but new methods are needed to support longer maintenance.

About Professor Lean

  • Visiting professor at University of Otago, and University of Sydney.
  • Established the first Department of Human Nutrition in a Scottish Medical School, 1990- initially funded 10 years by Rank Prize Funds.
  •  ‘Broad-focus’ strategy: translational, integrative, research and teaching, across all scientific disciplines within Human Nutrition.
  • Main focusses are on obesity, diabetes, metabolic syndrome and health promotion.
  • Awards include Diabetes UK-Rank Prize Lecture (2014), Banting Memorial Lecture (2020-21), Tenovus Medal for Research (2017)
  • Elected FRSE (National Academy of Scotland) (2018).

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February 20, 2023
1:00 pm - 2:00 pm
Event Category:


MRC Epidemiology Unit
01223 330315
View Organizer Website


Meeting rooms, Level 4 Institute of Metabolic Science, Addenbrooke’s Treatment Centre (ATC)
Cambridge Biomedical Campus
Cambridge, CB2 0SL United Kingdom
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