All are invited to the MRC Epidemiology Seminar:
This hybrid seminar was held in the meeting rooms, Level 4, Wellcome-MRC Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, and online.
Three RCT trials, conducted entirely in primary care using low-calorie formula diets for 8-12 weeks, have reported remissions for 40-60% of participants including South Asians, and 70-80% with weight loss >10kg, well maintained at 2 years. Hypertension and NAFLD, commonly accompanying T2D, normalized for ~30%. Remission was accompanied by normalization of ectopic fat in liver and pancreas, and insulin production capacity. With fewer serious adverse events, total medical care costs fell and cost-effectiveness analysis projected people to live longer, feel better and cost less. Remissions are strongly driven by weight loss, but new methods are needed to support longer maintenance.
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