MRC Epidemiology Unit
An international collaboration led by scientists from the University of Cambridge and Berlin Institute of Health at Charité (BIH) has discovered more than 300 regions in the genome that contribute to each person’s individual chemical fingerprint. Their results, published today in Nature Medicine, show how variations between individuals at these regions affect how our body […]
Detecting the undetected: measuring levels of three proteins in the blood can aid detection of undiagnosed prediabetes
Scientists have used a proteomics approach to identify a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes. The research, led by scientists from the MRC Epidemiology Unit and Berlin Institute of Health at Charité Universitätsmedizin, Germany, is published today in Nature Medicine. Medical and behavioural […]
Fenland Study finds widening inequalities in physical activity and diet during the COVID-19 pandemic
Findings from a Cambridgeshire study published in the journal Public Health show that diet quality and physical activity levels fell substantially during the pandemic compared to pre-pandemic levels. The fall was greatest in those living in less affluent areas. If these behaviour changes persist, this could have a considerable impact on widening inequalities, with those […]
Proteogenomic analysis explains why some people suffer more from COVID-19 than others
A large number of people are still contracting COVID-19. Fortunately, most of them are experiencing only mild symptoms, largely thanks to the high vaccination rate. However, in some individuals the disease takes a much more severe cause and our understanding about the underlying reasons is still insufficient. The human genome may hold a key to […]
COVID-19 Study demonstrates potential for at home blood sample collection
The ability to collect a blood sample painlessly from people at home without the need of a healthcare worker visit could transform the way healthcare and health research are conducted. This has been demonstrated by new study results published on 10 May 2022 in the Journal of Telemedicine and Telecare. Lockdown learning At the height […]
Metabolomic study links inhaled cortical steroid treatment for asthma to adrenal suppression
Inhaled cortical steroids (ICS) can help patients manage asthma symptoms, and recent updates to asthma treatment guidelines have expanded recommendations for low-dose treatment. But concerns persist that ICS may reduce production of the steroid hormone cortisol in the body leading to adrenal suppression. While initial adrenal suppression symptoms are subtle, continued progression can lead to […]
Combining proteomics techniques reveals importance of protein structure to health
In a study undertaken in more than 10,000 individuals, and published today in Nature Communications, scientists have shown that integrating information derived from different technologies to measure proteins can identify otherwise hidden links between proteins and human health and disease. The international research team led by scientists from the Medical Research Council (MRC) Epidemiology Unit […]
How our brain uses nutritional state to regulate growth and age at puberty
Scientists have discovered how a receptor in the brain, called MC3R, detects the nutritional state of the body and regulates the timing of puberty and rate of growth in children and increases in lean muscle mass. These findings, published today in the journal Nature, may explain how humans have been growing taller and reaching sexual […]
Filling the gaps: connecting genes to diseases through proteins
Hundreds of connections between different human diseases have been uncovered through their shared origin in our genome by an international research team led by Unit scientists, challenging the categorisation of diseases by organ, symptoms, or clinical speciality. A new study published in Science today generated data on thousands of proteins circulating in our blood and […]
Young adults at highest risk of weight gain
Young adults aged 18 to 24 are at the highest risk of becoming overweight or developing obesity in the next decade of their life compared to adults in any other age group, and obesity prevention policies should target this group, finds a new study co-led by researchers at the MRC Epidemiology Unit and University College […]
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