Evidence has been available for the risk of developing type 2 diabetes (T2D) varying by dietary habits, physical activity, smoking habits, and weight maintenance. However, there is little quantitative evidence about the potential impact of a combination of these factors on T2D risk in the United Kingdom or other nations.
This proposed work will address the following aims. i) To summarise available evidence for lifestyle-related factors associated with T2D risk; ii) To quantify the potential bias due to misreporting and measurement errors in the summary evidence; iii) To use the collected information to estimate how many T2D cases in future may relate to the suboptimal distribution of the risk factors in the United Kingdom. The estimation will be further extended to simulate the impact of potential population-level interventions. This work will include individual-participant longitudinal analysis, meta-analysis, and nationally-representative survey analysis.