MRC Epidemiology Unit
An international collaboration led by scientists from the University of Cambridge and Berlin Institute of Health at Charité (BIH) has discovered more than 300 regions in the genome that contribute […]
Detecting the undetected: measuring levels of three proteins in the blood can aid detection of undiagnosed prediabetes
Scientists have used a proteomics approach to identify a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes. The research, led […]
Proteogenomic analysis explains why some people suffer more from COVID-19 than others
A large number of people are still contracting COVID-19. Fortunately, most of them are experiencing only mild symptoms, largely thanks to the high vaccination rate. However, in some individuals the […]
Metabolomic study links inhaled cortical steroid treatment for asthma to adrenal suppression
Inhaled cortical steroids (ICS) can help patients manage asthma symptoms, and recent updates to asthma treatment guidelines have expanded recommendations for low-dose treatment. But concerns persist that ICS may reduce […]
Combining proteomics techniques reveals importance of protein structure to health
In a study undertaken in more than 10,000 individuals, and published today in Nature Communications, scientists have shown that integrating information derived from different technologies to measure proteins can identify […]
How our brain uses nutritional state to regulate growth and age at puberty
Scientists have discovered how a receptor in the brain, called MC3R, detects the nutritional state of the body and regulates the timing of puberty and rate of growth in children […]
Filling the gaps: connecting genes to diseases through proteins
Hundreds of connections between different human diseases have been uncovered through their shared origin in our genome by an international research team led by Unit scientists, challenging the categorisation of […]
Rare genetic variants confer largest increase in type 2 diabetes risk seen to date
Scientists at the University of Cambridge have identified rare genetic variants – carried by one in 3,000 people – that have a larger impact on the risk of developing type […]
Ethnic diversity in research identifies more genomic regions linked to diabetes-related traits
By including multi-ethnic participants, a largescale genetic study has identified more regions of the genome linked to type 2 diabetes-related traits than if the research had been conducted in Europeans […]
New study finds shared origins for individual chronic diseases in multimorbidity
A new study published today in Nature Medicine has identified key risk factors that increase the likelihood of individuals developing not only one but multiple non-communicable diseases, which include cardiovascular disease, […]