Programme Leaders – Prof Nick Wareham & Dr Claudia Langenberg
This programme serves the following Unit Objectives as a main focus:
- To investigate the causes of obesity, diabetes and related metabolic disorders
- To develop understanding of mechanisms identified by population-based studies
- To develop new methods, resources and tools for epidemiological and public health research
It serves the following Unit Objectives as an element of the programme:
- To develop and evaluate individual level approaches to the prevention of diabetes, obesity and related metabolic disorders in children and adults
- To build capacity for conducting, understanding and using local, national, and international epidemiology and public health research
- To contribute to the translation of research evidence into policy and practice
Diabetes is a chronic disorder of glucose metabolism and is a major cause of heart disease and premature death. The number of people with diabetes is rising worldwide. Between 35–40% of people in Europe will develop diabetes over their lifetime.
It has been suggested that type 2 diabetes originates from an interaction between genetic and lifestyle behaviour factors such as physical activity and diet. Together these factors influence glucose metabolism and the development of diabetes.
To improve the health of the public we need to understand the causes (aetiology) of diabetes and to develop ways of preventing the disease. We aim to identify how genetic and environmental factors influence the risk of type 2 diabetes and related metabolic disorders.
The two main projects of our research are the EU-funded InterAct and the genome-wide association study of insulin-glucose metabolism.
The InterAct Project
This study is designed to investigate how genetic and lifestyle behavioural factors, particularly diet and physical activity, interact in their influence on the risk of developing type 2 diabetes.
InterAct uses data from EPIC-Europe. EPIC is the European Prospective Investigation into Cancer and Nutrition, a large study of diet and health that has recruited over half a million (520,000) people across Europe. EPIC was designed to investigate the relationships between diet, nutritional status, lifestyle and environmental factors and the incidence of cancer and other chronic diseases. InterAct is using data from EPIC to identify genes and lifestyle factors that interact and influence the risk of diabetes. The project brings together existing trials to test whether the success of lifestyle interventions on diabetes risk may differ according to an individual’s genetic make-up.
- Find out more about the InterAct Project
Insulin-glucose metabolism study
Genetic changes specific to type 2 diabetes have recently been found through studies of the human genome. We aim to understand the mechanisms controlling the early development of type 2 diabetes at the genetic level. We are doing this by performing a genome-wide study of gene characteristics related to type 2 diabetes, such as glucose and insulin levels and signs of insulin resistance and beta-cell function. We now have data from more than 7,000 individuals who have been characterised for 500,000 genetic variations.
- Heba Al-Alwan – Visiting Scientist
- Raghib Ali – Senior Clinical Research Associate
- Tom Bishop – Senior Data Scientist
- Effrossyni Gkrania-Klotsas – Career Development Fellow
- Nicola Kerrison – Data Scientist
- Mine Koprulu – Ph.D. Student
- Claudia Langenberg – Programme Leader
- Chen Li – Ph.D. Student
- Chunxiao Li – Ph.D. Student
- Linda Oude Griep – Senior Research Associate
- Maik Pietzner – Research Associate
- Julia Carrasco Zanini Sanchez – Ph.D. Student
- Carina Tyrrell – Academic Clinical Fellow
- Nick Wareham – Director and Programme leader
- Alice Williamson – Ph.D. Student
Programme alumni (since 2014)
- Erlend Aasheim – Visiting Worker
- Dr Ali Abbasi – Senior Investigator Scientist
- Vicky Au Yeung – Ph.D. Student
- Nick Bowker – Ph.D. Student
- Lina Cai – Ph.D. Student
- Marco Carbone – Visiting Scientist
- A. Mesut Erzurumluoglu – Senior Research Associate
- Maria Hughes – Visiting Research Fellow
- Sherly Li – Ph.D. Student
- Luca A. Lotta – Senior Clinical Investigator
- Jake Mann– Visiting Clinical fellow
- Erin Oerton – Research Associate
- Clara Podmore – Wellcome Trust Clinical Ph.D. Fellow
- Robert Scott – Senior Investigator Scientist
- Eleanor Wheeler – Senior Research Associate
- Sara Willems – Career Development Fellow
- Laura Wittemans – Ph.D. Student
- Dan Wright – Ph.D. Student
- Zheng Ye – Investigator Scientist
- Yaling Zhao – Visiting Scientist
See all Aetiology and Mechanisms of Diabetes and Related Metabolic Disorders of Later Life publications in the MRC Epidemiology Unit Publications Database.