The Anglo-Danish-Dutch Study of Intensive Treatment In People with Screen Detected Diabetes in Primary Care (ADDITION study) was initiated in 1999. The primary objectives of the study were:
- To evaluate whether population-based screening for undiagnosed type 2 diabetes was feasible in a primary care setting
- To assess whether subsequent optimised intensive treatment of diabetes and associated risk factors among screen-detected patients were feasible in primary care and benefitted the patients, and
- To quantify the harms associated with screening. Previous screening studies have focused on people with pre-diabetes and how to prevent progression from pre-diabetes to diabetes.
The study consists of a screening phase followed by a pragmatic trial of intensive treatment compared to routine care in four centres (Denmark, Cambridge UK, the Netherlands and Leicester UK).